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Synthesis and sar studies for the inhibition of tnf-α production. part 2. 2-[3-(cyclopentyloxy)-4-methoxyphenyl]-substituted-1 -isoindolinone derivatives.

Archives of pharmacal research

Park JS, Moon SC, Baik KU, Cho JY, Yoo ES, Byun YS, Park MH.
PMID: 27518060
Arch Pharm Res. 2002 Apr;25(2):137-42. doi: 10.1007/BF02976553.

This study describes the synthesis andin vitro evaluation of 2-[3-(cyclopentyloxy)-4-methox-yphenyl]-1-isoindolinone derivatives substituted on benzene moiety of isoindoline ring for the inhibition of TNF-α production. From this study, we have found the 6-C position on isoindolinone ring is an optimal...

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Park JS, Moon SC, Baik KU, et al. Synthesis and sar studies for the inhibition of tnf-α production. part 2. 2-[3-(cyclopentyloxy)-4-methoxyphenyl]-substituted-1 -isoindolinone derivatives. Arch Pharm Res. 2002;25(2):137-42doi: 10.1007/BF02976553.
Park, J. S., Moon, S. C., Baik, K. U., Cho, J. Y., Yoo, E. S., Byun, Y. S., & Park, M. H. (2002). Synthesis and sar studies for the inhibition of tnf-α production. part 2. 2-[3-(cyclopentyloxy)-4-methoxyphenyl]-substituted-1 -isoindolinone derivatives. Archives of pharmacal research, 25(2), 137-42. https://doi.org/10.1007/BF02976553
Park, Joon Seok, et al. "Synthesis and sar studies for the inhibition of tnf-α production. part 2. 2-[3-(cyclopentyloxy)-4-methoxyphenyl]-substituted-1 -isoindolinone derivatives." Archives of pharmacal research vol. 25,2 (2002): 137-42. doi: https://doi.org/10.1007/BF02976553
Park JS, Moon SC, Baik KU, Cho JY, Yoo ES, Byun YS, Park MH. Synthesis and sar studies for the inhibition of tnf-α production. part 2. 2-[3-(cyclopentyloxy)-4-methoxyphenyl]-substituted-1 -isoindolinone derivatives. Arch Pharm Res. 2002 Apr;25(2):137-42. doi: 10.1007/BF02976553. PMID: 27518060.
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Vitamin C blocks TNF-α-induced NF-kB activation and ICAM-1 expression in human neuroblastoma cells.

Archives of pharmacal research

Son EW, Mo SJ, Rhee DK, Pyo S.
PMID: 27518391
Arch Pharm Res. 2004 Oct;27(10):1073. doi: 10.1007/BF02975434.

Interactions of the cell adhesion molecules are known to play important roles in mediating inflammation. The proinflammatory cytokine, tumor necrosis factor-α (TNF-α), activates the NF-kB signaling pathway, which induces the expression of various genes, such as intercellular adhesion molecule-1...

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Son EW, Mo SJ, Rhee DK, et al. Vitamin C blocks TNF-α-induced NF-kB activation and ICAM-1 expression in human neuroblastoma cells. Arch Pharm Res. 2004;27(10):1073doi: 10.1007/BF02975434.
Son, E. W., Mo, S. J., Rhee, D. K., & Pyo, S. (2004). Vitamin C blocks TNF-α-induced NF-kB activation and ICAM-1 expression in human neuroblastoma cells. Archives of pharmacal research, 27(10), 1073. https://doi.org/10.1007/BF02975434
Son, Eun-Wha, et al. "Vitamin C blocks TNF-α-induced NF-kB activation and ICAM-1 expression in human neuroblastoma cells." Archives of pharmacal research vol. 27,10 (2004): 1073. doi: https://doi.org/10.1007/BF02975434
Son EW, Mo SJ, Rhee DK, Pyo S. Vitamin C blocks TNF-α-induced NF-kB activation and ICAM-1 expression in human neuroblastoma cells. Arch Pharm Res. 2004 Oct;27(10):1073. doi: 10.1007/BF02975434. PMID: 27518391.
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Optimization of Astaxanthin microencapsulation in hydrophilic carriers using response surface methodology.

Archives of pharmacal research

Nalawade P, Gajjar A.
PMID: 26670178
Arch Pharm Res. 2015 Dec 15; doi: 10.1007/s12272-015-0693-5. Epub 2015 Dec 15.

Astaxanthin (3, 3'-dihydroxy-β, β-carotene-4, 4'-dione; AST) belongs to class of xanthophylls and is very effective antioxidant. It has very poor aqueous solubility resulting in lower bioavailability which presents major concerns in product development for oral use. AST was microencapsulated...

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Nalawade P, Gajjar A. Optimization of Astaxanthin microencapsulation in hydrophilic carriers using response surface methodology. Arch Pharm Res. 2015;doi: 10.1007/s12272-015-0693-5.
Nalawade, P., & Gajjar, A. (2015). Optimization of Astaxanthin microencapsulation in hydrophilic carriers using response surface methodology. Archives of pharmacal research, . https://doi.org/10.1007/s12272-015-0693-5
Nalawade, Pravin, and Gajjar, Anuradha. "Optimization of Astaxanthin microencapsulation in hydrophilic carriers using response surface methodology." Archives of pharmacal research vol. (2015). doi: https://doi.org/10.1007/s12272-015-0693-5
Nalawade P, Gajjar A. Optimization of Astaxanthin microencapsulation in hydrophilic carriers using response surface methodology. Arch Pharm Res. 2015 Dec 15; doi: 10.1007/s12272-015-0693-5. Epub 2015 Dec 15. PMID: 26670178.
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Investigation on the effect of polymer and starch on the tablet properties of lyophilized orally disintegrating tablet.

Archives of pharmacal research

Liew KB, Peh KK.
PMID: 25579848
Arch Pharm Res. 2021 Aug;44(8):1-10. doi: 10.1007/s12272-014-0542-y. Epub 2015 Jan 13.

Orally disintegrating tablet (ODT) is a user friendly and convenient dosage form. The study aimed to investigate the effect of polymers and wheat starch on the tablet properties of lyophilized ODT, with dapoxetine as model drug. Three polymers (hydroxypropylmethyl...

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Liew KB, Peh KK. Investigation on the effect of polymer and starch on the tablet properties of lyophilized orally disintegrating tablet. Arch Pharm Res. 2015;44(8):1-10doi: 10.1007/s12272-014-0542-y.
Liew, K. B., & Peh, K. K. (2021). Investigation on the effect of polymer and starch on the tablet properties of lyophilized orally disintegrating tablet. Archives of pharmacal research, 44(8), 1-10. https://doi.org/10.1007/s12272-014-0542-y
Liew, Kai Bin, and Peh, Kok Khiang. "Investigation on the effect of polymer and starch on the tablet properties of lyophilized orally disintegrating tablet." Archives of pharmacal research vol. 44,8 (2021): 1-10. doi: https://doi.org/10.1007/s12272-014-0542-y
Liew KB, Peh KK. Investigation on the effect of polymer and starch on the tablet properties of lyophilized orally disintegrating tablet. Arch Pharm Res. 2021 Aug;44(8):1-10. doi: 10.1007/s12272-014-0542-y. Epub 2015 Jan 13. PMID: 25579848.
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Saponin from the fruit of Solanum anguivi protects against oxidative damage mediated by Fe.

Archives of pharmacal research

Elekofehinti OO, Kamdem JP, Meinerz DF, Kade IJ, Adanlawo IG, Rocha JB.
PMID: 26160066
Arch Pharm Res. 2015 Jul 10; doi: 10.1007/s12272-014-0536-9. Epub 2015 Jul 10.

Solanum anguivi fruit saponin has antidiabetic property via interference with cellular energy metabolism and inhibition of reactive oxygen species (ROS) generation. In the current study, brain specific in vitro anti-oxidant role of S. anguivi saponin was investigated in the...

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Elekofehinti OO, Kamdem JP, Meinerz DF, et al. Saponin from the fruit of Solanum anguivi protects against oxidative damage mediated by Fe. Arch Pharm Res. 2015;doi: 10.1007/s12272-014-0536-9.
Elekofehinti, O. O., Kamdem, J. P., Meinerz, D. F., Kade, I. J., Adanlawo, I. G., & Rocha, J. B. (2015). Saponin from the fruit of Solanum anguivi protects against oxidative damage mediated by Fe. Archives of pharmacal research, . https://doi.org/10.1007/s12272-014-0536-9
Elekofehinti, Olusola Olalekan, et al. "Saponin from the fruit of Solanum anguivi protects against oxidative damage mediated by Fe." Archives of pharmacal research vol. (2015). doi: https://doi.org/10.1007/s12272-014-0536-9
Elekofehinti OO, Kamdem JP, Meinerz DF, Kade IJ, Adanlawo IG, Rocha JB. Saponin from the fruit of Solanum anguivi protects against oxidative damage mediated by Fe. Arch Pharm Res. 2015 Jul 10; doi: 10.1007/s12272-014-0536-9. Epub 2015 Jul 10. PMID: 26160066.
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Sequence specificity for DNA interstrand cross-linking induced by anticancer drug chlorambucil.

Archives of pharmacal research

Yoon JH, Lee CS.
PMID: 18982258
Arch Pharm Res. 1997 Dec;20(6):550-4. doi: 10.1007/BF02975210.

Chlorambucil is known to alkylate primarily N7 of guanine and N3 of adenine to induce DNA monofunctional adducts and interstrand cross-links (ISC). We have investigated the sequence specificity for DNA ISC induced by chlorambucil using duplex oligomers containing a...

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Yoon JH, Lee CS. Sequence specificity for DNA interstrand cross-linking induced by anticancer drug chlorambucil. Arch Pharm Res. 1997;20(6):550-4doi: 10.1007/BF02975210.
Yoon, J. H., & Lee, C. S. (1997). Sequence specificity for DNA interstrand cross-linking induced by anticancer drug chlorambucil. Archives of pharmacal research, 20(6), 550-4. https://doi.org/10.1007/BF02975210
Yoon, J H, and Lee, C S. "Sequence specificity for DNA interstrand cross-linking induced by anticancer drug chlorambucil." Archives of pharmacal research vol. 20,6 (1997): 550-4. doi: https://doi.org/10.1007/BF02975210
Yoon JH, Lee CS. Sequence specificity for DNA interstrand cross-linking induced by anticancer drug chlorambucil. Arch Pharm Res. 1997 Dec;20(6):550-4. doi: 10.1007/BF02975210. PMID: 18982258.
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Stimulation of troutCYP1A gene expression in mouse HEPA-1 cells by 3-methylcholanthrene.

Archives of pharmacal research

Lee SY, Sheen YY.
PMID: 18982480
Arch Pharm Res. 1997 Oct;20(5):404-9. doi: 10.1007/BF02973930.

TroutCYP1A-CAT expression construct was generated by cloning approximately 3.5 Kb 5' flanking DNA of trout liverCYP1A gene in front of CAT gene at pCAT-basic vector. Hepa 1 cells, which are known to contain a functional arylhydrocarbon receptor' were transfected...

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Lee SY, Sheen YY. Stimulation of troutCYP1A gene expression in mouse HEPA-1 cells by 3-methylcholanthrene. Arch Pharm Res. 1997;20(5):404-9doi: 10.1007/BF02973930.
Lee, S. Y., & Sheen, Y. Y. (1997). Stimulation of troutCYP1A gene expression in mouse HEPA-1 cells by 3-methylcholanthrene. Archives of pharmacal research, 20(5), 404-9. https://doi.org/10.1007/BF02973930
Lee, S Y, and Sheen, Y Y. "Stimulation of troutCYP1A gene expression in mouse HEPA-1 cells by 3-methylcholanthrene." Archives of pharmacal research vol. 20,5 (1997): 404-9. doi: https://doi.org/10.1007/BF02973930
Lee SY, Sheen YY. Stimulation of troutCYP1A gene expression in mouse HEPA-1 cells by 3-methylcholanthrene. Arch Pharm Res. 1997 Oct;20(5):404-9. doi: 10.1007/BF02973930. PMID: 18982480.
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Determination of isoprenyl and lavandulyl positions of flavonoids fromSophora flavescens by NMR experiment.

Archives of pharmacal research

Ryu SY, Lee HS, Kim YK, Kim SH.
PMID: 18982496
Arch Pharm Res. 1997 Oct;20(5):491-5. doi: 10.1007/BF02973946.

All fifteen flavonoids (1 approximately 15) have been isolated from the roots ofSophora flavescens (Leguminosae) as active principles of the cytotoxic property toward human tumor cell lines such as A549, SK-OV-3, SK-Mel-2, XF498 and HCT15,in vitro. By means of...

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Ryu SY, Lee HS, Kim YK, et al. Determination of isoprenyl and lavandulyl positions of flavonoids fromSophora flavescens by NMR experiment. Arch Pharm Res. 1997;20(5):491-5doi: 10.1007/BF02973946.
Ryu, S. Y., Lee, H. S., Kim, Y. K., & Kim, S. H. (1997). Determination of isoprenyl and lavandulyl positions of flavonoids fromSophora flavescens by NMR experiment. Archives of pharmacal research, 20(5), 491-5. https://doi.org/10.1007/BF02973946
Ryu, S Y, et al. "Determination of isoprenyl and lavandulyl positions of flavonoids fromSophora flavescens by NMR experiment." Archives of pharmacal research vol. 20,5 (1997): 491-5. doi: https://doi.org/10.1007/BF02973946
Ryu SY, Lee HS, Kim YK, Kim SH. Determination of isoprenyl and lavandulyl positions of flavonoids fromSophora flavescens by NMR experiment. Arch Pharm Res. 1997 Oct;20(5):491-5. doi: 10.1007/BF02973946. PMID: 18982496.
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Synthesis of novel heterocycles through reaction of indolin-2-one derivatives with active methylene and amino reagents.

Archives of pharmacal research

Abdel-Latif FF, Ahmed EK, Mekheimer R, Mashaly MM.
PMID: 18982499
Arch Pharm Res. 1997 Oct;20(5):507-9. doi: 10.1007/BF02973949.

Several new spiro compounds were synthesized via one-pot ternary condensation of isatin, malononitrile and each of thiobarbituric acid, barbituric acid, 3-methyl-pyrazolin-5-one, 1-phenyl-3-methyl-pyrazolin-5-one, acetylacetone, benzoylacetone, ethyl acetoacetate, phenacyl cyanide or ethyl-cyanoacetate dimer. Structures and reaction mechanism were reported and supported...

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Abdel-Latif FF, Ahmed EK, Mekheimer R, et al. Synthesis of novel heterocycles through reaction of indolin-2-one derivatives with active methylene and amino reagents. Arch Pharm Res. 1997;20(5):507-9doi: 10.1007/BF02973949.
Abdel-Latif, F. F., Ahmed, E. K., Mekheimer, R., & Mashaly, M. M. (1997). Synthesis of novel heterocycles through reaction of indolin-2-one derivatives with active methylene and amino reagents. Archives of pharmacal research, 20(5), 507-9. https://doi.org/10.1007/BF02973949
Abdel-Latif, F F, et al. "Synthesis of novel heterocycles through reaction of indolin-2-one derivatives with active methylene and amino reagents." Archives of pharmacal research vol. 20,5 (1997): 507-9. doi: https://doi.org/10.1007/BF02973949
Abdel-Latif FF, Ahmed EK, Mekheimer R, Mashaly MM. Synthesis of novel heterocycles through reaction of indolin-2-one derivatives with active methylene and amino reagents. Arch Pharm Res. 1997 Oct;20(5):507-9. doi: 10.1007/BF02973949. PMID: 18982499.
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A rubrofusarin gentiobioside isomer from roastedCassia tora.

Archives of pharmacal research

Lee HJ, Jung JH, Kang SS, Choi JS.
PMID: 18982501
Arch Pharm Res. 1997 Oct;20(5):513-5. doi: 10.1007/BF02973951.

From the roasted seeds ofCassia tora L., a new naphthopyrone glycoside was isolated and characterized as 10-[(beta-D-glucopyranosyl-(1-->6)-O-beta-D-glucopyranosyl)oxyl-5-hydroxy-8-methoxy-2-methyl-4H-naphtho [1,2-b]pyran-4-one(isorubrofusarin gentiobioside). Along with isorubrofusarin gentiobioside, alaternin and adenosine were isolated and identified.

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Lee HJ, Jung JH, Kang SS, et al. A rubrofusarin gentiobioside isomer from roastedCassia tora. Arch Pharm Res. 1997;20(5):513-5doi: 10.1007/BF02973951.
Lee, H. J., Jung, J. H., Kang, S. S., & Choi, J. S. (1997). A rubrofusarin gentiobioside isomer from roastedCassia tora. Archives of pharmacal research, 20(5), 513-5. https://doi.org/10.1007/BF02973951
Lee, H J, et al. "A rubrofusarin gentiobioside isomer from roastedCassia tora." Archives of pharmacal research vol. 20,5 (1997): 513-5. doi: https://doi.org/10.1007/BF02973951
Lee HJ, Jung JH, Kang SS, Choi JS. A rubrofusarin gentiobioside isomer from roastedCassia tora. Arch Pharm Res. 1997 Oct;20(5):513-5. doi: 10.1007/BF02973951. PMID: 18982501.
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Synthesis of new xanthenone derivatives of expected antibilharzial activity.

Archives of pharmacal research

Omar MT.
PMID: 18982267
Arch Pharm Res. 1997 Dec;20(6):602-9. doi: 10.1007/BF02975219.

A new series of 1,3,4-oxadiazoles, 1,3,4-thiadiazoles and 1,2,4-triazoles incorporated directly and/or indirectly into a xanthenone moiety at position-2 were synthesized. Some of the newly prepared compounds were biologically tested as schistosomicides in experimental animals.

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Omar MT. Synthesis of new xanthenone derivatives of expected antibilharzial activity. Arch Pharm Res. 1997;20(6):602-9doi: 10.1007/BF02975219.
Omar, M. T. (1997). Synthesis of new xanthenone derivatives of expected antibilharzial activity. Archives of pharmacal research, 20(6), 602-9. https://doi.org/10.1007/BF02975219
Omar, M T. "Synthesis of new xanthenone derivatives of expected antibilharzial activity." Archives of pharmacal research vol. 20,6 (1997): 602-9. doi: https://doi.org/10.1007/BF02975219
Omar MT. Synthesis of new xanthenone derivatives of expected antibilharzial activity. Arch Pharm Res. 1997 Dec;20(6):602-9. doi: 10.1007/BF02975219. PMID: 18982267.
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Effect of food on the pharmacokinetics of YH439 and its metabolites in rats.

Archives of pharmacal research

Kim MK, Ahn BN, Yoo JK, Lee JW.
PMID: 18982270
Arch Pharm Res. 1997 Dec;20(6):629-32. doi: 10.1007/BF02975222.

The pharmacokinetics of YH439 and its metabolites were investigated after oral administration of YH439 to rats to investigate the food effect. After oral administration of YH439, its metabolites, M4 and M5 were detected in plasma. YH439 was not detected...

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Kim MK, Ahn BN, Yoo JK, et al. Effect of food on the pharmacokinetics of YH439 and its metabolites in rats. Arch Pharm Res. 1997;20(6):629-32doi: 10.1007/BF02975222.
Kim, M. K., Ahn, B. N., Yoo, J. K., & Lee, J. W. (1997). Effect of food on the pharmacokinetics of YH439 and its metabolites in rats. Archives of pharmacal research, 20(6), 629-32. https://doi.org/10.1007/BF02975222
Kim, M K, et al. "Effect of food on the pharmacokinetics of YH439 and its metabolites in rats." Archives of pharmacal research vol. 20,6 (1997): 629-32. doi: https://doi.org/10.1007/BF02975222
Kim MK, Ahn BN, Yoo JK, Lee JW. Effect of food on the pharmacokinetics of YH439 and its metabolites in rats. Arch Pharm Res. 1997 Dec;20(6):629-32. doi: 10.1007/BF02975222. PMID: 18982270.
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Showing 1 to 12 of 249 entries